Helps Regulate the Expression of Aging-Related Factors (SASP), Support Cellular Health, and Maintain Vitality and Well-Being

Quercetin and Fisetin: Exploring Healthy Aging Through Natural Fruits and Vegetables

Why Does Our Body Seem to “Age” as We Grow Older?

When we talk about aging, we are referring to more than just changes in our appearance.

As we grow older, some cells in the body gradually enter a state known as cellular senescence. These cells no longer divide normally, yet they are not always removed immediately by the body. Instead, they may continue releasing substances that affect nearby cells and the surrounding cellular environment.

These substances are collectively associated with what scientists call the senescence-associated secretory phenotype, or SASP.

Simply put:

Senescent cells do not just age themselves—they may also send signals that influence the environment around neighboring cells.

For this reason, healthy-aging research is beginning to explore whether naturally occurring plant compounds in our everyday diet may help regulate mechanisms related to cellular aging, alongside maintaining a balanced diet and a healthy lifestyle.

Among the natural compounds receiving considerable research attention are quercetin and fisetin.

Quercetin: A Natural Phytonutrient Found in Fruits and Vegetables

Quercetin is a naturally occurring flavonoid found in a wide variety of plants.

It is more common in our everyday diet than many people realize. Foods such as onions, apples, berries, grapes, and tomatoes all contain quercetin.

Previous studies have explored quercetin for its antioxidant properties and its potential role in regulating inflammation-related responses. In recent years, it has also attracted attention in the field of healthy aging because researchers have found that it may be associated with the survival of senescent cells and mechanisms related to SASP.

In other words, research into quercetin now extends beyond its antioxidant properties to include its possible relationship with cellular aging.

Fisetin: A Natural Phytonutrient Found in Fruit

Another natural compound of interest is fisetin.

Like quercetin, fisetin is a naturally occurring plant flavonoid. It can be found in foods such as strawberries, apples, persimmons, onions, and grapes.

Cellular and animal studies suggest that fisetin may influence mechanisms associated with senescent cells. As a result, it has become another natural compound of interest in healthy-aging research.

Both fisetin and quercetin belong to a group of naturally occurring plant compounds known as polyphenols.

This has led researchers to consider an important question:

Beyond providing essential nutrients, could the fruits and vegetables we eat every day contain even more beneficial plant compounds worth exploring?

Have Human Studies Been Conducted?

The answer is yes, although the research is still at an early stage.

Some human studies involving older adults and people with chronic health conditions have examined the effects of quercetin used in combination with other compounds on senescent cells.

The results showed changes in certain indicators associated with cellular senescence and SASP, further increasing scientific interest in the relationship between quercetin and cellular aging.

However, these studies have generally involved relatively small numbers of participants. Some have also examined quercetin in combination with pharmaceutical compounds. Therefore, their findings should not be interpreted as evidence that consuming quercetin alone can prevent or reverse aging.

Research on fisetin currently consists mainly of cellular and animal studies, while human evidence remains relatively limited.

A more scientifically responsible conclusion is:

Quercetin and fisetin show potential in the study of cellular-aging-related mechanisms, but further human research is still needed to confirm their effects.

Why Do We Pay Particular Attention to SASP?

Imagine a room containing several pieces of old furniture.

If the furniture is simply old, it may not cause much of a problem. However, if it continually releases substances that gradually affect the surrounding environment, the condition of the entire room may eventually be influenced.

The relationship between senescent cells and SASP can be understood in a similar way.

For this reason, healthy-aging research is not only concerned with how cells age. Researchers are also exploring another important question:

How can we maintain a healthier cellular environment?

Natural plant compounds such as quercetin and fisetin are among the areas that scientists continue to investigate.

Bringing the Goodness of Natural Fruits and Vegetables into Everyday Life

At RegenoMed, we believe that health should not remain merely a scientific concept discussed in laboratories. It should also be connected to the food we eat every day.

Beginning with natural fruits and vegetables, we carefully select plant-derived nutrients and develop products that can be conveniently incorporated into daily meals—including Senolytic Sauce.

Senolytic Sauce is carefully prepared using natural fruits and vegetables and is made without added food additives. It contains plant-derived components such as quercetin, fisetin, urolithins, polyphenols, and dietary fiber.

Each gram contains approximately one trillion plant-derived extracellular vesicles. Through processes such as emulsification and fruit-acid adjustment, followed by low-temperature pasteurization, we aim to maintain food safety and storage stability while preserving more of the naturally occurring active components found in plants.

Our focus is not limited to one individual ingredient. Instead, we value the diverse combination of plant nutrients naturally present in fruits and vegetables.

Scientists continue to explore the relationships between antioxidant activity, cellular health, SASP, and other mechanisms associated with cellular aging.

Our goal is to bring these natural plant nutrients into everyday life in a simpler and more convenient way.

Healthy aging does not have to begin only when we grow older.

By starting with the food we eat every day, we can take small steps today to build a healthier future.

Senolytic Sauce | Bringing plant-based nutrition from natural fruits and vegetables into your everyday diet.